This paper is concerned with the numerical simulation of a thermodynamically compatibleviscoelastic shear-thinning fluid model, particularly well suited to describe therheological response of blood, under physiological conditions. Numerical simulations areperformed in two idealized three-dimensional geometries, a stenosis and a curved vessel,to investigate the combined effects of flow inertia, viscosity and viscoelasticity inthese geometries. The aim of this work is to provide new insights into the modeling andsimulation of homogeneous rheological models for blood and a basis for furtherdevelopments in modeling and prediction.