Fine details of morphological changes in biological structures, which approach the resolution limits of a microscope or detection device, are often difficult to determine. These difficulties are compounded if imaging of living specimens is required. In this work we use a variety of software approaches to enhance individual images removed from a video of thrombocyte (platelet) activation on a glass coverslip. Through software approaches, fine details and focal depth were significantly improved in images of pseudopodia from activated thrombocytes.
