Researchers who are fortunate enough to collect large datasets sometimes wish to publish multiple papers using the same dataset. Unfortunately, there are few guidelines that authors can follow in managing these multiple papers. In this article, we address three main questions including: (i) how do authors know if they have a dataset truly worthy of multiple papers; (ii) what procedures do authors follow when they are ready to submit multiple papers from a single dataset to top tier journals; and (iii) what are the main issues when attempting to publish multiple papers from a single dataset? We provide a set of concrete recommendations for authors who wish to maximize their data collection efforts with multiple papers.