An exploration of cabinet leadership in Mexico has always provided insights into political recruitment trends for leading policymakers. An examination of the present cabinet from 2012 through 2016 is valuable for four reasons. First, to what extent does the current leadership reflect changes in compositional patterns of the most influential policymakers as a result of a democratic electoral process dating from 2000? Second, does the return of the PRI reflect traditional patterns established by the last two PRI presidential administrations, or has the present cabinet taken on features that can be attributed to the two previous PAN administrations? Third, have significant patterns emerged, reflected in recent appointments, that suggest influential characteristics exercising broader influences in the future? Fourth, will the most influential cabinet figures under the PRI presidency reestablish their dominance as leading contenders for their party’s presidential election in 2018?