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1 results

  • 15 - Diagnostic dilemmas in cellular pathology

  • from SECTION 4 - Diagnostic Dilemmas
  • Edited by Sean Kehoe, Eric Jauniaux, Pierre Martin-Hirsch, Philip Savage
  • Book:
    Cancer and Reproductive Health
    Published online:
    05 October 2014
    Print publication:
    01 November 2008, pp 179-184

  • Summary

    There are many diagnostic dilemmas in gynaecological cellular pathology, spanning across all age groups. This chapter considers the six most challenging pathological entities in the reproductive age group. The dilemmas in ovarian cysts arises when the cyst is deemed to be complex as there may be a reluctance to aspirate in case of spillage of malignant cells. The most significant diagnostic dilemma with regard to cervical neoplasia is in the staging of microinvasive carcinoma. All the diagnostic difficulties in cervical neoplasia are compounded by the need to excise as small a piece of the cervix as possible to preserve fertility and prevent miscarriage. The problem with the diagnosis of atypical hyperplasia is in the vague criteria used for cytological atypia, rounding up of nuclei with clearing of chromatin and prominent nucleoli, which results in considerable variation of opinion among pathologists.