This article sets out to reconsider the history of curse tablets in the ancient Mediterranean world as the history of a technology, one marked by episodes of innovation and appropriation. Attempts to write a history in terms of diffusion or of the spread of classical ideas or of magic have failed to convince, and most recent studies focus on the particularities of specific tablets or groups of tablets. This article argues that, if human and object agency are taken into account, it is possible to explain both the discontinuities in the history of curse tablets and also the shape of their thousand-year history. Curse tablets emerge as a technology the affordances of which allowed it to be put to many uses in many different social locations formed by the complex and shifting cultural contours of antiquity.