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duodenitis

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Chapter 15 - Coeliac Disease
- By Colan M. Ho-Yen, Fuju Chang
Edited by Roger M. Feakins
Book:

Non-Neoplastic Pathology of the Gastrointestinal Tract

Published online:

06 June 2020

Print publication:

09 July 2020, pp 215-235
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Summary

A common clinical indication for duodenal biopsy is the exclusion of coeliac disease / gluten sensitive enteropathy. However, a variety of inflammatory and infectious disorders may affect the duodenum, some of which are associated with subtle endoscopic findings. The indications for duodenal biopsy are often the same as the broader indications for upper gastrointestinal endoscopy and include chronic dyspepsia, unexplained anaemia, abdominal pain, bloating, nausea, and diarrhoea. Endoscopic findings associated with inflammatory duodenal biopsies range from normal-appearing duodenal mucosa to mild hyperaemia and congestion of the duodenal bulb to erosions, severe congestion, mucosal haemorrhage, mucosal contact bleeding, and luminal narrowing.