The early results on astrochemistry from the Cores to Disks (c2d) Legacy program are summarized. The c2d program focuses on the formation of low-mass stars in nearby (within about 300 pc) clouds. Spectroscopy with IRS includes the following topics: ices seen against background stars, in protostellar envelopes, and in disks; grain growth and mineralogy, PAHs, and gas in circumstellar disks.