This chapter reviews the current assisted reproductive technology (ART) outcome analysis process in the United States to expand the reader's perspective and understanding of its complexity and explores progress toward meaningful collection, analysis, and interpretation of ART outcomes by clinician and patient in the future. The Society for Assisted Reproductive Technology (SART), an affiliate organization of the American Society for Reproductive Medicine (ASRM), worked with the Centers for Disease Control and prevention (CDC) as the initial purveyor of data collection and publication, representing reproductive specialists and the majority of domestic ART practices. Ovarian reserve, diagnosis-specific therapy, laboratory prowess, practice management philosophies, therapeutic access, and patient demographics play an intricately intertwined role in determining successful outcome. Patient selection/rejection is acknowledged as powerful influences of ART outcome but is practiced to different degrees by any individual physician/practice.