A novel reconfigurable circular microstrip G-slotted antenna having a circularly defected ground structure (DGS) capable of switching its resonance frequency for several microwave applications is presented in this paper. Reconfigurability of the proposed G-slot antenna is obtained by incorporating three PIN diodes. One diode is embedded in the patch and two diodes are integrated into the DGS structure at appropriate places in the slot to achieve four different wireless applications such as aeronautical radio navigation (4.3 GHz with gain 3.6 dB), satellite communication (3.78 GHz with gain 3.7 dB), mobile communication (4.55 GHz with gain 4.0 dB), and WiMAX (3.35 GHz with gain 3.3 dB). These four bands are achieved depending on the different biasing conditions of the three PIN switches used. Antenna performance has been analyzed in ANSYS Electronics Desktop 2018.2 software. The equivalent circuit component of the switching element (PIN diode) has been considered and designed during the simulation. The creative structure lies in the way that it exhibits higher gain with compact size than the previously reported similar antenna. A prototype of the proposed patch antenna has been fabricated on a Roger substrate and its testing and measurement have been performed to demonstrate its desirable characteristics and features.