The spread and application of enterprise information systems (EISs) has provided scholars and managers with a new perspective to enhance the work–family enrichment. Based on the work–family enrichment theory, this research aims to examine the ability of female employees to enhance their work–family enrichment by applying the resources accumulated through the use of EISs by combining the technology acceptance model with the DeLone & McLean Information Systems Success Model. The findings based on a survey of 823 full-time female employees in China indicated that the information systems quality factors (including information quality, system quality, and service quality) were positively associated with female employees’ work–family enrichment. In addition, the chained mediating effect of perceived ease of use and perceived usefulness was examined. The results can help female employees to perform positively in both work and family spheres and provide positive support for the promotion of the social fertility policies.