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2 results

  • Chapter 19 - Overcoming Decline (in) Narrative

  • from Part III - Applications: Politics
  • Edited by Anna M. Elsner, Universität St Gallen, Switzerland, Monika Pietrzak-Franger, Universität Wien, Austria
  • Book:
    Literature and Medicine
    Published online:
    17 January 2024
    Print publication:
    18 January 2024, pp 330-344

  • Summary

    This chapter explores how the culturally and medically prized concept of narrative influences pessimism about ageing. Taking dementia as a situation where anxieties about ageing and continuity of self are particularly acute, it illustrates the pressure emanating from narrativity for life as lived and life as narrated, revealing episodicity as a viable response to this two-fold pressure. Reading life histories of older people, it additionally shows that episodicity is hugely relevant also for how life is pitched retrospectively. Overall, this chapter argues that a stronger focus on episodic self-experience throughout life has the potential to challenge aspects of the decline narrative that nourishes pessimism about ageing.

  • Familiality and SNP heritability of age at onset and episodicity in major depressive disorder

  • P. Ferentinos, A. Koukounari, R. Power, M. Rivera, R. Uher, N. Craddock, M. J. Owen, A. Korszun, L. Jones, I. Jones, M. Gill, J. P. Rice, M. Ising, W. Maier, O. Mors, M. Rietschel, M. Preisig, E. B. Binder, K. J. Aitchison, J. Mendlewicz, D. Souery, J. Hauser, N. Henigsberg, G. Breen, I. W. Craig, A. E. Farmer, B. Müller-Myhsok, P. McGuffin, C. M. Lewis
  • Journal:
    Psychological Medicine / Volume 45 / Issue 10 / July 2015
    Published online by Cambridge University Press:
    20 February 2015, pp. 2215-2225
    • Article
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  • Background

    Strategies to dissect phenotypic and genetic heterogeneity of major depressive disorder (MDD) have mainly relied on subphenotypes, such as age at onset (AAO) and recurrence/episodicity. Yet, evidence on whether these subphenotypes are familial or heritable is scarce. The aims of this study are to investigate the familiality of AAO and episode frequency in MDD and to assess the proportion of their variance explained by common single nucleotide polymorphisms (SNP heritability).

    Method

    For investigating familiality, we used 691 families with 2–5 full siblings with recurrent MDD from the DeNt study. We fitted (square root) AAO and episode count in a linear and a negative binomial mixed model, respectively, with family as random effect and adjusting for sex, age and center. The strength of familiality was assessed with intraclass correlation coefficients (ICC). For estimating SNP heritabilities, we used 3468 unrelated MDD cases from the RADIANT and GSK Munich studies. After similarly adjusting for covariates, derived residuals were used with the GREML method in GCTA (genome-wide complex trait analysis) software.

    Results

    Significant familial clustering was found for both AAO (ICC = 0.28) and episodicity (ICC = 0.07). We calculated from respective ICC estimates the maximal additive heritability of AAO (0.56) and episodicity (0.15). SNP heritability of AAO was 0.17 (p = 0.04); analysis was underpowered for calculating SNP heritability of episodicity.

    Conclusions

    AAO and episodicity aggregate in families to a moderate and small degree, respectively. AAO is under stronger additive genetic control than episodicity. Larger samples are needed to calculate the SNP heritability of episodicity. The described statistical framework could be useful in future analyses.