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The post-COVID-19 condition describes the persistence or onset of somatic symptoms (e.g. fatigue) after acute COVID-19. Based on an existing cognitive-behavioral treatment protocol, we developed a specialized group intervention for individuals with post-COVID-19 condition. The present study examines the feasibility, acceptance, and effectiveness of the program for inpatients in a neurological rehabilitation setting.
Methods
The treatment program comprises eight sessions and includes psychoeducational and experience-based interventions on common psychophysiological mechanisms of persistent somatic symptoms. A feasibility trial was conducted using a one-group design in a naturalistic setting. N = 64 inpatients with a history of mild COVID-19 that fulfilled WHO criteria for post-COVID-19 condition were enrolled. After each session, evaluation forms were completed and psychometric questionnaires on somatic and psychopathological symptom burden were collected pre- and post-intervention.
Results
The treatment program was well received by participants and therapists. Each session was rated as comprehensible and overall satisfaction with the sessions was high. Pre-post effect sizes (of standard rehabilitation incl. new treatment program; intention-to-treat) showed significantly reduced subjective fatigue (p < 0.05, dav = 0.33) and improved disease coping (ps < 0.05, dav = 0.33–0.49).
Conclusions
Our results support the feasibility and acceptance of the newly developed cognitive-behavioral group intervention for individuals with post-COVID-19 condition. Yet, findings have to be interpreted cautiously due to the lack of a control group and follow-up measurement, the small sample size, and a relatively high drop-out rate.
Rigorous evaluation of interventions is vital to advance the science of behavior change and identify effective interventions. Although randomized controlled trials (RCTs) are often considered the “gold standard”, other designs are also useful. Considerations when choosing intervention design are the research questions, the stage of evaluation, and different evaluation perspectives. Approaches to explore the utility of an intervention, include a focus on (1) efficacy; (2) “real-world” effectiveness; (3) how an intervention works to produce change; or (4) how the intervention interacts with context. Many evaluation designs are available: experimental, quasi-experimental, and nonexperimental. Each has strengths and limitations and choice of design should be driven by the research question. Choosing relevant outcomes is an important step in planning an evaluation. A typical approach is to identify one primary outcome and a narrow range of secondary outcomes. However, focus on one primary outcome means other important changes may be missed. A well-developed program theory helps identify a relevant outcomes. High-quality evaluation requires (1) involvement of relevant stakeholders; (2) evaluating and updating program theory; (3) consideration of the wider context; (4) addressing implementation issues; and (5) appropriate economics input. Addressing these can increase the quality, usefulness, and impact of behavior change interventions.
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