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The well-being of the fetus is strongly influenced by the status of the critically ill mother. Understanding basic principles of placental gas exchange is important when caring a pregnant patient in the intensive care unit (ICU). Aside from the few cases in which delivery is the preferred therapy, managing a pregnant patient in ICU should focus primarily on maternal well-being and only secondarily on the effects of interventions on the fetus. If preterm delivery is anticipated, administration of antenatal corticosteroids to the mother will decrease rates of common complications of prematurity of the newborn. The usual rule is to optimize the maternal medical condition and allow the fetus and placenta to take care of themselves. Certain fetal conditions such as severe intrauterine growth restriction may also provide a reason to separate the fetus from the mother.
The origin of placental septa and the orifices of spiral arteries have been the subject of great controversy. The anatomy of the venous drainage has also been the subject of much discussion. The intrusive cells in the lumen as described by C. Friedlander were intensively studied by J. D. Boyd and W. J. Hamilton using their large collection of uterine specimens with the placenta in situ. The delivered placenta and fetal membranes were for many years the commonest method of obtaining material for the study of spiral artery pathology, and there were large discrepancies between the findings in this material. The method of placental bed biopsy produced useful material, but nevertheless was criticized by Hamilton and Boyd. The spiral artery anatomy as well as the vascular pathology were only revealed after studying uteri with in situ placentae pregnancy that compromise both maternal and fetal health.
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