Motivated by applications in data science, we study partial differential equations on graphs. By a classical fixed-point argument, we show existence and uniqueness of solutions to a class of nonlocal continuity equations on graphs. We consider general interpolation functions, which give rise to a variety of different dynamics, for example, the nonlocal interaction dynamics coming from a solution-dependent velocity field. Our analysis reveals structural differences with the more standard Euclidean space, as some analogous properties rely on the interpolation chosen.