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3 results

  • Social Cognition in Temporal and Frontal Lobe Epilepsy: Systematic Review, Meta-analysis, and Clinical Recommendations

  • Maryam Ziaei, Charlotte Arnold, Kate Thompson, David C. Reutens
  • Journal:
    Journal of the International Neuropsychological Society / Volume 29 / Issue 2 / February 2023
    Published online by Cambridge University Press:
    07 March 2022, pp. 205-229
    • Article
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  • Objective:

    Despite the importance of social cognitive functions to mental health and social adjustment, examination of these functions is absent in routine assessment of epilepsy patients. Thus, this review aims to provide a comprehensive overview of the literature on four major aspects of social cognition among temporal and frontal lobe epilepsy, which is a critical step toward designing new interventions.

    Method:

    Papers from 1990 to 2021 were reviewed and examined for inclusion in this study. After the deduplication process, a systematic review and meta-analysis of 44 and 40 articles, respectively, involving 113 people with frontal lobe epilepsy and 1482 people with temporal lobe epilepsy were conducted.

    Results:

    Our results indicated that while patients with frontal or temporal lobe epilepsy have difficulties in all aspects of social cognition relative to nonclinical controls, the effect sizes were larger for theory of mind (g = .95), than for emotion recognition (g = .69) among temporal lobe epilepsy group. The frontal lobe epilepsy group exhibited significantly greater impairment in emotion recognition compared to temporal lobe. Additionally, people with right temporal lobe epilepsy (g =  1.10) performed more poorly than those with a left-sided (g = .90) seizure focus, specifically in the theory of mind domain.

    Conclusions:

    These data point to a potentially important difference in the severity of deficits within the emotion recognition and theory of mind abilities depending on the laterlization of seizure side. We also suggest a guide for the assessment of impairments in social cognition that can be integrated into multidisciplinary clinical evaluation for people with epilepsy

  • Chapter 16 - Psychiatric illness and psychotropic medication use in epilepsy

  • Edited by Michael R. Trimble, Institute of Neurology, London, Bettina Schmitz
  • Book:
    The Neuropsychiatry of Epilepsy
    Published online:
    07 October 2011
    Print publication:
    09 June 2011, pp 165-196

  • Summary

    To date neurobiological interest in the behavioral consequences of epilepsy has been concerned primarily with the neuropsychology of temporal lobe epilepsy (TLE) and of mesial temporal lobe epilepsy (mTLE) in particular. In epilepsy several factors can be discerned, which can lead to dynamic and principally reversible changes in the patient's behaviors and mood states. The patient with epilepsy must always be seen in his or her state relative to seizures. Epileptic activity can affect distant brain areas and cause cognitive and behavioral problems beyond the primary lesion. Antiepileptic drugs may have positive or negative psychotropic side effects, and can show incompatibilities in the individual patient. Very special behavioral and neuropsychological conditions are met during nonconvulsive status epilepticus (NCSE). The chapter concludes that in temporal and frontal lobe epilepsy dysfunctional behaviors can be discerned which characteristically correspond to the affected brain regions.

  • Chapter 17 - Psychiatric effects of surgery for temporal lobe epilepsy

  • Edited by Michael R. Trimble, Institute of Neurology, London, Bettina Schmitz
  • Book:
    The Neuropsychiatry of Epilepsy
    Published online:
    07 October 2011
    Print publication:
    09 June 2011, pp 197-208

  • Summary

    Imaging and lesion studies have identified cerebral networks associated with social cognitive functions which are frequently affected in patients with temporal or frontal lobe epilepsies. Processing of emotional information plays an important role in many aspects of cognition, including decision-making, memory, and attention. The perception and expression of emotional information and theory of mind (ToM) abilities have been investigated in numerous studies in a variety of patient groups and healthy persons using a number of experimental paradigms and tests. The chapter presents short descriptions and behavioral data from a variety of tests in order to reveal their differences and to highlight recent developments and research perspectives. Mesial temporal lobe epilepsy (MTLE) is the most prevalent focal epilepsy. Structure-function analyses have also shown an association between impairments in the recognition of facial expressions, especially of fear and reduced fMRI activity in patients with early onset right-sided TLE.