In 1868 a cholera epidemic erupted in the north-western Argentine province of Tucumán. Urban-based doctors and politicians argued that fruit cultivated primarily in the south of the province was responsible for the spread of cholera. Hoping to avoid cholera, they advocated the complete prohibition and destruction of fruit in Tucumán as both a prophylactic measure, but also to prepare new land for sugar cultivation. Through a reading of governmental memos, medical journals, and public health reports, this article examines how agriculture, disease, and contagion mediated the interaction between Tucumán's urban minority and rural majority. This article offers a window into grassroots politics and state formation during one of Argentina's most formative periods.