Two seemingly unrelated topics are discussed—an outlook for biofuels in the southern United States, along with an overview of the important role that information technology is playing in the fuel ethanol industry. The outlook discussion is limited to issues involving the two principal biofuels, fuel ethanol and biodiesel, and their respective feed stocks, corn and soybean oil. The two topics are linked with a description of how information technology (IT) has enabled the development of the fuel ethanol franchise and a discussion of how IT is changing the very nature of biofuel operations.