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  • 5 - Statistical approaches in psychopharmacogenetics

  • from Part II - Clinical background and research design
    • By Fabio Macciardi, Center for Addiction and Mental Health, University of Toronto. Toronto, Canada
  • Edited by Bernard Lerer, Hadassah-Hebrew Medical Center, Jerusalem
  • Book:
    Pharmacogenetics of Psychotropic Drugs
    Published online:
    20 August 2009
    Print publication:
    29 August 2002, pp 72-92

  • Summary

    The statistical analysis of data in psychopharmacogenetics is a key factor in the evaluation of importance of gene or a set of genes in controlling the response to a given drug or to explain the emergence of side effect as a consequence of the administered drug. The association strategy conceptually entails the candidate gene paradigm based on a 'forward genetics' design. This chapter explains how to analyze the genetic architecture of a pharmacogenetic trait. First, a definition of a pharmacogenetic trait is presented, with the consequential methods of analysis, followed by some considerations for defining a phenotype suitable for investigation. Then, the chapter deals with genetic polymorphisms, with a particular focus on single nucleotide polymorphisms (SNPs). The chapter concludes with a discussion on ethnic and interindividual differences in the distribution of genetic variants, and explains how they can affect any investigation.