Yellow starthistle, spotted knapweed, and meadow hawkweed are three competitive noxious weeds that collectively infest about 640,000 ha of range and noncropland in Idaho. The purpose of this study was to determine the control of these three noxious weeds and undesirable annual grasses with imazapic applied at different rates and growth stages. Imazapic applied fall preemergence, spring postemergence (POST), or fall plus spring POST and picloram applied fall and spring POST reduced yellow starthistle plant density 75 to 100% compared with the untreated control, at about 100 d after spring treatment (DAST). However, by 440 DAST, yellow starthistle plant density did not differ from the untreated control in plots treated with imazapic, whereas picloram reduced plant density 82 to 99%. Imazapic did not control meadow hawkweed or spotted knapweed, whereas picloram reduced plant density of both species 91 to 100% 60 DAST compared with the untreated control and 71 to 100% 440 DAST. Imazapic did not affect weedy annual grass plant density compared with the untreated control at the yellow starthistle or the spotted knapweed sites. However, at the meadow hawkweed sites, imazapic applied spring POST at 210 g/ha and fall plus spring POST at 70 plus 140 g/ha reduced grass plant density 77 to 84% 60 DAST. All treatments that contained spring-applied imazapic reduced grass plant density 46 to 92%, 440 DAST at the meadow hawkweed site. At all locations, picloram increased weedy annual grass plant density two- to eightfold 440 DAST compared with the untreated control. Imazapic offers only moderate control of weedy annual grasses for a brief period after application and does not provide control of these three major noxious weed species in the West. Unfortunately, it eliminates a fairly new rangeland herbicide from the list of potential tank mix partners for control of auxinic herbicide–resistant weed species.