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Trying to assess the way sex differences in behavior are reflected in the brain, neuroscience reports produced diverse results triggering hot discussions on whether such differences exist and/or are worth considering in further studies. This chapter summarizes recent progress in the study of sex/gender effect on the brain as viewed from the perspective of (1) anatomy, which is based on the description of various global and local morphometric features of male and female brain structures; and (2) connections, which conceptualizes the brain as a large-scale network of structures interconnected within the human connectome which subserves the transmission and integration of information at both global and local levels. It is argued that the key to understanding the behavioral differentiation of the two sexes might lie in the differences in the architecture of their networks rather than in morphometric measures of particular structures and tissues.
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