Many common agronomic practices affect weed seed dormancy and germination by influencing the microenvironmental and edaphic conditions surrounding seeds in soil. Factors such as light penetration, soil water content, soil fertility, and temperature are modified by tillage, planting, harvesting, and other production practices, resulting in enhanced or depressed weed seed germination. Changes in these environmental factors may also indirectly lead to alterations in phytohormone concentrations during seed development, which can subsequently affect dormancy status of the mature seed. Integrated approaches that place priority on depleting weed seed banks through interfering with dormancy or germination requirements have strong potential to enhance weed management aspects of agricultural systems.