In nature, science and engineering, we often come across helicoidal surfaces. A curve on a helicoidal surface in Euclidean 3-space is called a loxodrome if the curve intersects all meridians at a constant azimuth angle. Thus loxodromes are important in navigation. In this paper, we find the differential equation of the loxodrome on a helicoidal surface in Euclidean 3-space. Also we give some examples and draw the corresponding pictures via the Mathematica computer program to aid understanding of the mathematics of navigation.