In a world of weaponized interdependence, middle powers have policy choices that can enhance their autonomy. However, having this policy space is not enough. In order to turn the policy space into policy enactment, domestic politics has to align in a particular way. This chapter considers India and Brazil as examples of “middle powers” and analyzes their capacity to enact autonomy and safeguard their digital sovereignty. The authors argue that when independent institutions’ interests are incorporated into the policymaking process and are not usurped by the parliamentary (political) process, they observe the enactment of autonomy-enhancing policies. Brazil’s and India’s data localization policies are illustrative case studies. While Brazil and India are both open democracies with a technoeconomic landscapes characterized by a similar technoeconomic landscape with a hybrid mixture of foreign-owned and domestically owned companies, they have adopted different data localization policies. The authors argue that the divergent paths of Brazil and India are due to the nature of the policymaking process. India’s policymaking incorporated the interests of independent institutions. In contrast, Brazil’s parliamentary process usurped policymaking power from its independent institutions and has not yet granted the mandate and tools to either existing or necessary new institutions, such as regulatory agencies, to address this emerging and already pressing set of issues. Thus, for countries to enact policies to enhance their digital sovereignty, the interests of independent institutions must be incorporated, and their power must be increased.