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1 results

  • Radiotherapy for histiocytic sarcoma: a case report

  • Daniel J. Bourgeois III, Allison Dixon, Anurag K. Singh
  • Journal:
    Journal of Radiotherapy in Practice / Volume 14 / Issue 2 / June 2015
    Published online by Cambridge University Press:
    09 January 2015, pp. 212-215
  • Background

    Histiocystic sarcoma is a rare, but aggressive tumour that often involves extranodal sites. Histiocystic sarcoma is recognised by the World Health Organization as one of six subtypes of dendritic cell neoplasms. Diagnosis is difficult due to overlapping immunohistochemistry with other dendritic cell neoplasms. The optimal roles for chemotherapy, radiotherapy and surgery in the treatment of histiocytic sarcoma remain unknown.

    Methods

    We report a case of a patient with histiocytic sarcoma diagnosed after excisional biopsy and immunohistochemistry testing.

    Results

    The patient underwent external beam radiation therapy (EBRT). After 18 Gray (Gy), the 8 cm lesion had regressed to ~5 cm in diameter. The treatments were continued to a total dose of 45 Gy with the lesion regressing to less than a centimeter by the end of treatment. Local control was maintained but the patient died of acute myelogenous leukemia 5 months after her treatment.

    Conclusions

    This case suggests that histicytic sarcomas can be controlled locally with EBRT.