The opening chapter introduces the reader to the ongoing genome-editing revolution, which is spearheaded by the discovery of CRISPR. To set the appropriate context for the book, the chapter discusses human ingenuity, its presence throughout the history of civilization, and the power it holds to transform the world. The chapter lays out a foundation on which to argue that transformative technologies—such as the printing press, the Internet, nuclear weapons, and other technological feats that induced massive cultural and social change—share a common modus operandi. This exposition aims to help the audience grasp the significance of having access to the specialized tools required to rationally manipulate the genetic composition of living organisms. The chapter provides a high-level overview of the book’s contributions to the literature and discusses the importance of interdisciplinary inquiry to bridge gaps between science, law, and policy.

The introduction’s core purpose is to emphasize to the reader that the potential impact of genome editing is likely to be on par with—if not greater than—the discovery of nuclear fission, which led to the development of nuclear weapons, or the advent of modern computing, which spawned the era of worldwide communications via the Internet.

To understand what puritans were doing in New England, we have to begin elsewhere, for the place of New England is itself not a beginning but a consequence – an effect of causes long in process before there ever were colonists at Plymouth, Salem, or Boston. Puritanism originated many decades before as a movement for reform of worship and the church in Scotland and England, a movement committed to a certain understanding of redemption – the passage from sin to salvation in the Christian life – that had wide-ranging social, political, and theological ramifications. This chapter maps the basic features of that movement and carries the dynamics forward into the “puritan revolution” of c. 1640–1660, including the theological currents that swirled beyond 1660. Tracking how Calvinist ideas circulated from the Continent to England and Scotland and what impact those ideas had on society, this chapter spells out the origins of puritanism and describes the battles and transatlantic dynamics that shaped American puritan literature.