Applying conservation of resources theory, we propose a theoretical model that explains how and when supervisor knowledge sharing affects creative behavior. Specifically, this study examines employee self-efficacy as the core intermediary mechanism and work–family conflict as the boundary condition of the indirect effect of supervisor knowledge sharing on creative behavior via self-efficacy. Drawn from a sample of 147 dyads comprising full-time employees and their immediate supervisors, the results of this study showed support for our moderated mediation model. The findings indicated that supervisor knowledge sharing had a significant effect on creative behavior and this influence is mediated by self-efficacy. Furthermore, our study revealed that work–family conflict attenuated the positive supervisor knowledge sharing's effect on creative behavior via self-efficacy. Implications of our findings for theory and practice are discussed.