In sandwich structures, mass can be reduced or mechanical properties increased if the challenging local load distribution can be improved. Through numerical optimizations, novel designs can be determined and investigated in physical and virtual tests. This paper presents an approach for load path-optimized design of sandwich structures and novel design concepts. The approach is applied to the design concept of honeycombs filled with potting compound. Due to the shown transferability to higher structural levels, it can be used as a basis for the design optimization of any sandwich structure.