The area of the Atures Rapids in the Middle Orinoco River (Venezuela), where multiple Indigenous communities gathered to trade goods, has been identified as a prominent center of commerce since early colonial times. However, the exchange activities taking place there between local and nonlocal actors before European colonization are poorly understood, based only on the ethnohistoric record. This article presents an archaeometric analysis of stone beads and ceramic roller stamps, items previously associated with trade practices, from two recently excavated sites in the region, Picure (AD 1030–1480) and Rabo de Cochino (AD 1000–1440); it assesses their provenance, production, and value. We propose that Picure was a site of a bead-manufacturing workshop and a place where roller stamps were exchanged. The stamps were acquired and produced by different potting groups. Analysis of the chaîne opératoire and production techniques shows processes of adaptation and emulation associated with the multiple, multiethnic communities during the period from AD 1000 to 1480. Both beads and stamps are linked to identity regalia that were likely used as part of ceremonies taking place in the area of the Rapids, as indicated by the numerous and monumental petroglyphs found on the islands.