Public interest in food systems has grown dramatically, and agricultural economists have important roles to play in contributing to and leading large-scale interdisciplinary studies of the subject. Key topics include understanding food system participants' behaviors and incentives and determining what food systems can and cannot achieve. I review a global food-security project funded by the National Institute of Food and Agriculture that illustrates the interactions between production, distribution, and consumption of food and regional self-reliance, as well as other important areas in which agricultural and regional economists can gainfully apply their tools and methods, including studies of the impacts of local food and network analyses.