This chapter summarizes current data on the maternal and fetal effects of nonobstetrical surgeries during pregnancy, including anesthesia, diagnostic and therapeutic management, laparoscopy, and the common general surgical pathologies found in the pregnant patient. Changes in maternal physiology during pregnancy due to gestational hormones and mechanical effects of the increasingly gravid uterus have an impact on anesthesia during nonobstetrical surgery. The American College for Obstetrics and Gynecology (ACOG) concluded that although there are no data to support specific recommendations for nonobstetrical surgery and anesthesia in pregnancy, it is important for physicians to obtain obstetric consultation before surgery. The fetal loss rate is significantly greater for pregnant patients undergoing appendectomy when compared to other surgical procedures during pregnancy. Laparoscopic management of adnexal masses in pregnancy is a safe and effective procedure compared to traditional surgery.