The brittle stars Ophiactis savignyi and Ophiothela mirabilis are documented for the first time from French Guiana. The latter species was associated with colonies of a gorgonian, Leptogorgia miniata, growing on a rocky reef beneath a brackish layer of water and above an unstable mud bottom. Ophiothela mirabilis is a recently established alien introduction to the Atlantic. Ophiothela discovered in French Guiana were located approximately midway between populations of O. mirabilis in Brazil and at St Vincent, and individuals from all three countries may represent a single lineage of ophiuroids. Evidence is presented that O. savignyi and O. mirabilis could have been transported to the Amazon Barrier region by shipping and/or by coastal currents linking Brazil, French Guiana and St Vincent. If oceanic circulation is responsible for its dispersal, it is predicted that O. mirabilis will spread from the Windward Islands toward the southern Caribbean coast, whereas dispersal by shipping could follow a more northerly route.