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The sudden emergence of a lethal virus necessitating social distancing required billions of students worldwide to engage in various forms of e-learning, the effects of which are currently unknown. In some instructional contexts, the overall proportion of e-learning relative to in-person classes may continue on an upward trajectory. A long-history of media comparison research shows that learning is less a function of the delivery medium and more reflective of instructional methods that support human cognitive processes. In this chapter I emphasize evidence-based e-learning methods that (1) manage mental load, (2) promote productive engagement, and (3) offer feedback that guides learners to improved responses. I discuss the use of these methods to guide the design of digital explanations, engagement opportunities, and feedback in synchronous and asynchronous e-learning. I also discuss emerging digital learning opportunities in the form of interactive virtual reality and learning games.
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