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leukocyte transendothelial migration

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5 - Molecular Mechanisms of Implantation
from PART I - PHYSIOLOGY OF REPRODUCTION
- By F. Domínguez, Carlos Simón, Juan A. Garcia-Velasco
Edited by Botros R. M. B. Rizk, University of South Alabama, Juan A. Garcia-Velasco, Hassan N. Sallam, Antonis Makrigiannakis, University of Crete
Book:

Infertility and Assisted Reproduction

Published online:

04 August 2010

Print publication:

15 September 2008, pp 46-52
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Summary

This chapter summarizes the information concerning the systems implicated in the regulation of implantation and endometrial receptivity in humans. If focuses on the chemokine system and the comparison of two similar processes, human implantation and leukocyte transendothelial migration. The chapter presents new strategies based on array technology that aim to clarify the fragmented information existing in the field. Clues about the relevance of the chemokines in the process of implantation come from the chemokine interferon inducible protein 10 kDa (IP-10). IP-10 has been involved in the regulation of blastocyst migration, apposition, and initial adhesion in ruminants. The ultimate goal of DNA microarrays technology is to establish a standard for recording and reporting microarray-based gene expression data, which will in turn facilitate the establishment of databases and public repositories and enable the development of data analysis tools.

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5 - Molecular Mechanisms of Implantation

Summary