Eugeniella palleola, Graphis paraschiffneri, and Malmidea cineracea are described from Nicaragua. Eugeniella palleola is characterized by having pale apothecial discs and prominent, white margins, and producing a complex chemistry including atranorin, stictic and norstictic acids, and an unknown substance. Graphis paraschiffneri has lirellae with a lateral thalline margin, striate labia, a completely carbonized excipulum, transversely septate ascospores, and contains norstictic acid in the thallus. Malmidea cineracea is characterized by a granulose-isidiate thallus with a yellowish medulla and a compact, crystal-encrusted excipulum. Malmidea nigromarginata and M. piperina are proposed as new combinations. Keys are presented to all known species of Eugeniella (9) and Malmidea (50).