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Vulvar carcinoma is a relatively rare cancer entity. However, this disease, in contrast to other gynaecological cancers, recently showed an increasing incidence, including young women. Despite showing a poor response on the administration of chemotherapeutics, vulvar carcinomas have excellent response to surgical treatment when detected in early stages. More than other cancer entities and especially in young females, treatment of vulvar cancer effects body image, sexuality, quality of life and sexual activity. Interdisciplinary decision making, a stage-conforming therapy accompanied with low invasiveness (e.g. lymphadenectomy using the sentinel technique) and further treatment regimens (e.g. radiation) are important steps to preserve the sensitivity and function of the vulva and adjacent organs. Surgical treatment procedures for vulvar cancers have changed during recent years towards tissue-sparing oncoplastic and reconstructive surgery. Previously applied radical surgical approaches, such as en-bloc resection, are often associated with high postoperative morbidity, vulvar deformity and sexual dissatisfaction.
Laparoscopic extensive myomectomy, hysterectomy for large myomas, laparoscopic treatment of endometriosis or treatment of cancer of the uterus are advanced laparoscopic gynaecological procedures. Since they can be very challenging, many special pre-, intra- and postoperative aspects need to be considered. This chapter aims to give insights into the different advanced laparoscopic gynaecological procedures. The preoperative arrangement, the intraoperative setting, key operative steps and the postoperative course are described in detail. An overview of common intraoperative complications like ureter injuries, bladder injuries, gastrointestinal injuries, vascular injuries and pneumoperitoneum-linked complications is given. Some typical postoperative complications like wound-healing problems, bleeding and gastrointestinal lesions are described together with possible treatment options.
This chapter describes the diagnosis, treatment, and prognosis for malignant melanoma during pregnancy. Clinical staging traditionally included assessment of the local tumor site and adjacent skin, regional lymph node areas, and distant organs that are frequently the site of metastatic disease. Surgical removal of the melanoma with adequate margins remains the standard primary therapy for early melanoma. Interim Multicenter Selective Lymphadenectomy Trial (MSLT-1) results revealed similar overall 5-year survival benefit between patients who had undergone wide excision and sentinel lymph node biopsy (SLNB) with immediate lymphadenectomy and those who had wide excision and postoperative observation of regional lymph node with lymphadenectomy if nodal relapse occurred. The risk of malformations when chemotherapy is administered in the first trimester is estimated to be around 7.5%-17% for single-agent chemotherapy and 25% for combination chemotherapy. The effect of pregnancy on prognosis of melanoma is a focus of interest in the medical literature for years.
Ovarian cancer is the fourth most common cause of cancer deaths in women and the leading cause of gynaecological cancer death in Europe with a lifetime prevalence in the developed world of 1-2%. Primary ovarian tumours are a heterogeneous group, which includes epithelial tumours, sex-cord stromal and germ-cell tumours. There are a number of indications for surgery for ovarian carcinoma: establishment of diagnosis, accurate staging, primary cytoreduction, interval and secondary cytoreduction, and palliative and salvage surgery. Modest improvement in progression-free survival in the lymphadenectomy arm was offset by increased morbidity. Although surgery is usually the primary treatment, ovarian cancer is a chemosensitive disease and chemotherapy has been shown to improve prognosis in advanced disease. Treatment for relapsed disease is usually regarded as a palliative measure in women with symptomatic recurrent tumours. Radiotherapy is mainly used as palliative treatment to reduce pain and, occasionally, to control bleeding.
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