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  • 6 - Tissue remodelling the fetal-maternal interface: the regulation of matrix metalloproteinase 9 transcription

  • from SECTION 1 - PREPARATION FOR IMPLANTATION – THE UTERINE ENVIRONMENT
  • Edited by Hilary Critchley, University of Edinburgh, Iain Cameron, University of Southampton, Stephen Smith
  • Book:
    Implantation and Early Development
    Published online:
    05 June 2014
    Print publication:
    01 June 2005, pp 70-78

  • Summary

    This chapter deals with the regulation of matrix metalloproteinase-9 (MMP9) transcription in tissue remodelling at the fetal-maternal interface. MMPs, also called matrixins, are a family of at least 20 human zinc-dependent endopeptidases collectively capable of degrading all components of the endometrial extracellular matrix (ECM) essentially. Gelatinase B (MMP9) is considered to be instrumental in trophoblast invasion since in vitro, it mediates cytotrophoblastic cells (CTB) invasion into a Matrigel. The MMP9 gene contains 13 exons and 12 introns for a total size of 7.7 kbp. The regulatory region of this gene has been described in two studies showing multiple cis-regulatory elements. These cis-regulatory elements are specific DNA sequences that bind trans-activators or trans-repressors (transcription factors), which are thus proteins encoded by other genes. As is the case with many other genes, MMP9 can be regulated by co-repressors or coactivators.