The development of mass dispensing clinics and mass vaccination clinics should be incorporated into community disaster plans. Federal assistance in the event of a large-scale public health emergency requiring mass antibiotic prophylaxis or vaccination includes obtaining necessary medications from several sources. In the United States, the Strategic National Stockpile (SNS) is a federally managed supply of antibiotics, vaccines, antitoxins, antivirals, medical supplies, and equipment that is available to affected areas once local, state, or regional supplies are depleted or systems are overwhelmed. Points of dispensing (PODs) operation are the mechanisms available for dispensing medication or administering vaccines to large population after a catastrophic event. Medication-related adverse events may be seen in varying numbers in a mass dispensing or mass vaccination campaign. Each POD location should have the appropriate equipment such as forklifts or pallet jacks to move deliveries as well as sufficient equipment to provide cold chain storage as needed.