In this paper, a completely reconfigurable comb-line bandpass filter is presented. Due to the modularity, different standard coupling matrix topologies like the folded form, cascaded triplets, and the cul-de-sac form can be implemented and tested. Circuit-based coupling matrices like the extracted pole topology can easily be realized as well. Different types of input-/output- and cross-couplings can be examined before fabrication of a fixed filter set-up takes place. Furthermore, the proposed filter platform can be used to construct a diplexer. By using different heights of the inner and outer conductor of the coaxial resonators, arbitrary center frequencies in the range between 1 and 4 GHz can be realized. Various types of input couplings are available and proposed here to achieve bandwidths between 10 and 110 MHz. A variety of cross-coupling apertures able to realize transmission zeros are presented as well.