In Brazil, as in most countries, history and natural history museums are the repositories of rich collections of excavated archaeological material. One of the major challenges in working with these collections is the paucity of information available regarding the original excavations, which raises important questions that archaeologists and museum studies professionals have been grappling with for several decades: what interpretive value do these collections have without any contextual information, and are they worth maintaining in museum archives that are facing continuing crises in space and resources? This article uses the concepts of entanglement and assemblage to discuss a collection of ceramics excavated from one of the first Spanish Jesuit missions in colonial Paraguay, San Ignacio Miní (1610–1631), and housed at the Museu Paranaense in Curitiba, Brazil. Despite the lack of contextual information from the 1963 excavation, we can begin to explore the entangled pasts, present, and future of these objects by tracing the trajectory of the collection from the initial formation through excavation and contemporary analysis. Innovative approaches are needed to address methodological and theoretical concerns in analyzing archaeological museum collections to ensure that the knowledge and potential insights entangled in these collections are not lost.