Kant claims that we cannot cognize the mutual interaction of substances without their being in space; he also claims that we cannot cognize a ‘spatial community’ among substances without their being in mutual interaction. I situate these theses in their historical context and consider Kant’s reasons for accepting them. I argue that they rest on commitments regarding the metaphysical grounding of, first, the possibility of mutual interaction among substances-as-appearances and, second, the actuality of specific distance-relations among such substances. By illuminating these commitments, I shed light on Kant’s metaphysics of space and its relation to Newton and Leibniz’s views.