This article examines attempts to modernise navigation of the Doce River in Brazil during the early nineteenth century. It focuses primarily on the development of a joint Anglo-Brazilian business venture, The Rio Doce Company (1832–49). The failure of the Rio Doce Company cannot be attributed to a single overarching cause, but reflects numerous barriers to economic development including a cumbersome regulatory bureaucracy, capital scarcity, poor technological integration, challenging topography, and Brazilian political resistance to British investment and corporate oversight. This article contributes to the field of business history in the immediate post-independence era, a topic that has received relatively little scholarly attention.