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1 results

  • Chapter 1.2 - Chapter

  • from 1 - Inflammatory Conditions
  • Edited by Derya Uluduz, Istanbul Üniversitesi
  • Anita Arsovska
  • Book:
    Rare Causes of Stroke
    Published online:
    06 October 2022
    Print publication:
    01 September 2022, pp 28-33

  • Summary

    Eosinophilic granulomatosis with polyangiitis (EGPA, previously named Churg– Strauss syndrome) is a form of necrotizing vasculitis occurring in patients with asthma and eosinophilia. Clinical manifestations are ranging from general symptoms like fever, arthralgias, myalgias and loss of weight, to involvement of virtually any organ system in the body. Nervous system involvement is usual and mainly concerns the peripheral nerves. Mononevritis multiplex is the most frequent finding, followed by peripheral neuropathy. Central nervous system is affected in almost 5% of patients. Ischemic stroke is a relatively rare complication of the disease. Several possible underlying mechanisms of stroke have been proposed: cardioembolism, vasculitis and/or direct eosinophilic infiltration. Given the rarity and the detrimental impact in quality of life and mortality, treatment in EGPA patients with stroke should be more aggressive in order to achieve clinical remission as quickly as possible. The mainstay of treatment is the combination of corticosteroids and immunosuppressants