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2 results

  • 37 - Amyloid and Tau PET Scans of My Brain

  • Daniel Gibbs, Emeritus of Oregon Health and Science University
  • Book:
    Dispatches from the Land of Alzheimer's
    Published online:
    19 January 2024
    Print publication:
    22 February 2024, pp 149-154

  • Summary

    In 2015 and again in 2018, I traveled to San Francisco to be a volunteer in a study of a then experimental PET scan for abnormal tau protein in the brain using a radioactive ligand called [18F]-AV1451. This radioactive ligand binds with high affinity to insoluble, paired-helical filaments of hyperphosphorylated tau, the principal component of neurofibrillary tangles. Although my three-year follow up scans were delayed by the Covid-19 pandemic, I returned with Lois in September, 2022 for third set of studies spread over two days. What made this visit different, other than having to wear masks throughout the visit, was the presence of the film crew that is making a documentary film based on my first book, A Tattoo on my Brain: A Neurologist’s Personal Battle against Alzheimer’s Disease.

  • Case 21 - Man with post-operative cognitive impairment

  • Edited by Serge Gauthier, McGill University, Montréal, Pedro Rosa-Neto, McGill University, Montréal
  • Book:
    Case Studies in Dementia
    Published online:
    16 May 2011
    Print publication:
    21 April 2011, pp 155-164

  • Summary

    This chapter talks about an 83-year-old man with a 3-4-year history of progressive speech difficulty. Past medical history was remarkable for hypertension and ischemic heart disease. Psychiatric history was unremarkable. General neurological exam was remarkable for bilateral cogwheeling in the upper extremities, rigid posture, and bilateral decreased arm swing. Magnetic Resonance Imaging (MRI) of the brain showed diffuse atrophy. Single-Photon Emission Computed Tomography (SPECT) showed decreased perfusion in the left temporo-parietal region. The findings suggested a diagnosis of progressive non-fluent aphasia (PNFA). The possibility of corticobasal syndrome (CBS) was also raised. A variety of neuropathological changes have been associated with PNFA. The most common are non-Alzheimer tauopathies. Alzheimer pathology has also being identified in PNFA, with some reports showing these in up to 30% of cases. In these patients, the distribution of AD pathology may be unusual, showing a frontotemporal pattern.