Research was conducted in 2012 and 2013 to evaluate the response of the rice cultivars ‘Cheniere', ‘CL151′, ‘Caffey', ‘CL261′, and ‘CLXL745′ response to POST applications of saflufenacil. Treatments included a nontreated control, saflufenacil at 50 g ai ha−1, and carfentrazone at 35 g ai ha−1 applied mid-POST (MPOST) to rice in the three- to four-leaf stage. Pooled across cultivars, injury was greatest at 3 and 7 d after treatment (DAT), 21 and 17%, respectively. Rice injury was only 5% at 14 DAT and 1% at 28 DAT. Hybrid long-grain cultivar CLXL745 was injured more than inbred long-grain cultivars CL151 and Cheniere. Cheniere was more tolerant than inbred medium-grain cultivars CL261 and Caffey. All cultivars exhibited tolerance to saflufenacil as evidenced by similar normalized difference vegetative index (NDVI), maturity, mature plant height, and rice yield (rough, whole, and total milled rice).