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  • 19 - Screening for early ovarian ageing

  • from SECTION 5 - FUTURE FERTILITY INSURANCE: SCREENING, CRYOPRESERVATION OR EGG DONORS?
  • Edited by Susan Bewley, William Ledger, University of New South Wales, Sydney, Dimitrios Nikolaou
  • Book:
    Reproductive Ageing
    Published online:
    05 February 2014
    Print publication:
    01 June 2009, pp 201-210

  • Summary

    A number of tests have been used to predict ovarian ageing/poor ovarian reserve. Despite the large number of tests in current use, an ideal test has yet to be developed. The most comprehensive systematic review for tests of ovarian reserve concluded that an in vitro fertilisation (IVF) cycle itself may be a more reliable predictor of ovarian response to stimulation than any of the existing tests. The predictive value of four of the most commonly used tests are: basal serum follicle-stimulating hormone, antral follicle count (AFC), serum inhibin B and serum antimillerian hormone (AMH). Internationally, a number of fertility prediction tests have been marketed, and the tests have been mainly developed within an IVF setting, using data on outcomes of ovarian stimulation. Serum AMH concentration and AFC tests can predict oocyte yield but not oocyte quality or pregnancy.