The paper suggests an innovative design research and intervention approach using a poststructuralist organizational education perspective. The potential of a high impact trans-epistemic design process is shown for the field of industry 4.0 and the specific context of cognitive assistive systems (CASs). The multi-layered approach addresses the design of technical, social and educational complexity to implement CASs sustainably on the shopfloor and exploit their potential in industry 4.0. Finally, we will shed light on how the approach can enhance deep organizational transformation in industry.