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1 results

  • Neuropeptidase activities in plasma after acute restraint stress. Interaction with cortico-limbic areas

  • Ana Belén Segarra, Joaquín Hernández, Isabel Prieto, Marc de Gasparo, Manuel Ramírez-Sánchez
  • Journal:
    Acta Neuropsychiatrica / Volume 28 / Issue 4 / August 2016
    Published online by Cambridge University Press:
    17 February 2016, pp. 239-243
  • Objective

    To evaluate the influence of acute restraint stress (ARS) on plasma enkephalinase and oxytocinase activities. ARS modifies basal activities in cortico-limbic regions of rats and induces changes in the correlations observed between these regions. The interactions between plasma and cortico-limbic activities will be also evaluated.

    Methods

    Enkephalinase (AlaAP and LeuAP) and oxytocinase (P-LeuAP) activities were fluorometrically determined in plasma of control and stressed rats using aminoacyl-β-naphthylamides (aaNNap), AlaNNap and LeuNNap as substrates.

    Results

    No differences in enzymatic activities were observed between control and stressed animals in plasma. In contrast, highly significant positive and negative correlations between plasma and cortico-limbic regions were demonstrated in controls. Stress conditions significantly alter the pattern of these correlations.

    Conclusion

    The present results clearly support a connection between plasma and brain involving certain neuropeptidase activities that change under stress conditions.