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1 results

  • 22 - Paediatric outcome after assisted reproductive technology

  • from SECTION 4 - CLINICAL SEQUELAE
  • Edited by Hilary Critchley, University of Edinburgh, Iain Cameron, University of Southampton, Stephen Smith
  • Book:
    Implantation and Early Development
    Published online:
    05 June 2014
    Print publication:
    01 June 2005, pp 268-280

  • Summary

    Plurality at birth is of prime importance and is the single most significant determinant of paediatric outcome after assisted reproductive technology (ART). The types of treatment used, such as in vitro fertilisation (IVF), intracytoplasmic sperm injection (ICSI), blastocyst transfer and others, become mere subtleties when faced with the birth of triplets. There is probably a continuum of risk between standard IVF and the more recent ICSI, with even more invasive forms of ART such as ICSI with testicular sperm aspiration (TESA) being of higher risk for the birth of children with birth defects. Doyle et al estimated that 20000 children would be required to observe a doubling or halving of the risk of childhood cancer in children conceived after ART compared with the general population. There has been some suggestion from a Swedish study that children born after IVF have an increased risk of developing neurological problems, particularly cerebral palsy.