Targeting weed patches for site-specific herbicide applications potentially represents cost savings for operators, reduction in environmental herbicide effects, and increased efficiency of weed control. An experiment was initiated in a no-till corn field in Ontario, Canada, in 1998 and was continued in rotation with no-till soybeans in 1999. Weeds were intensively scouted, and distribution maps of the most common weeds (field horsetail, spiny sowthistle, dandelion, and common lambsquarters) were generated for both years. A prescription map for each plot was made using the weed density maps. Treatment decisions were based on a weed threshold value of 1 shoot m−2. Four herbicide treatments were compared: a conventional broadcast, a site-specific application targeting weed patches only, and two combinations of broadcast and site-specific applications. Treatments were applied using a direct-injection sprayer. Efficacy of weed control and yield were compared among treatments. In 1998 and 1999 there were no differences in the level of weed control or yield among treatments. The average percent area sprayed was reduced as much as 26% in the site-specific treatment in 1998 and up to 59% in the site-specific and broadcast combination treatments in 1999. For those species present in the field, patches ranged from highly aggregated to completely random, and patch stability ranged from very stable to very unstable over the 2 yr.